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The following message was posted to: PharmPK
Dear PharmPK subscribers,
For distribution studies, I need to know how blood flow to the brain is
affected by moderate and strenuous exercise.
Thanks
Carolyn Nichol, Ph.D.
cnichol.-at-.rice.edu
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From: alex.macdonald.-a-.pharma.novartis.com
Date: Thu Feb 20, 2003 2:12:05 AM US/Central
To: david.-at-.boomer.org
Subject: Re: PharmPK Brain perfusion
Reply-To: alex.macdonald.aaa.pharma.novartis.com
The following message was posted to: PharmPK
Dear Carolyn,
Please find below references for two books which contain information on
changing perfusion rates and exercise.
Astrand, P.O. (1986). Textbook of Work Physiology: Physiological Bases
of Exercise. McGraw-Hill Education - Europe.
Fiserova-Bergerova, V. (Ed) 1983. Modeling of Inhalation Exposure to
Vapors: Uptake, Distribution, and Elimination.CRC Press.
(2 volumes, I can't remember which one has the chapter on exercise
physiology).
From my recollection the Astrand gives average human brain blood flow
values at rest and during heavy work. The Fiserova book provides values
for a
number
of work rates.
Best Regards
Alex
Dr. A.J.MacDonald
Principal Scientist
Novartis Pharma AG
Modelling and Simulation
ICPP-PCS,WKL135.1.67
CH4002,Basel
Switzerland
(T) +4161 696 77 98
(F) +41 61 696 69 92
---
From: wwolfw.-a-.usc.edu
Date: 20 Feb 2003
Carolyn:
This information could be gotten by either Dynamic MRI studies or by
Dynamic PET studies, both of which are good at measuring blood flow
noninvasively. Obviously, changes in blood flow to the heart during
exercise are extremely well studied and are routine clinical tests (now
done primarily using pharmacological stress rather than physical
exercise).
A few references that might get you started include:
K Ide and NH Secher, Cerebral blood flow and metabolism during
exercise. [Review] [115 refs] Progress in Neurobiology. 61(4):397-414,
2000.
Critchley HD. Corfield DR. Chandler MP. Mathias CJ. Dolan RJ. Cerebral
correlates of autonomic cardiovascular arousal: a functional
neuroimaging investigation in humans. [Journal Article] Journal of
Physiology. 523 Pt 1:259-70, 2000
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Dr. Nichol,
Prolonged strenuous exercise can result in a slight (less than 15%)
decrease in cerebral blood flow (Hellstrom G, Fischer-Colbrie W,
Wahlgren NG, Jogestrand T., J Appl Physiol 1996 Jul;81(1):413-8), but
if combined with strenuous exercise the decrease can exceed 20% (Nybo
L, Moller K, Volianitis S, Nielsen B, Secher NH., J Appl Physiol 2002
Jul;93(1):58-64). On the other hand, moderate exercise results in a
slight (~15%) increase in cerebral blood flow (also in the Hellstrom et
al article above). Cerebral metabolic rate remains more or less
constant in all these situations.
Arlin Blood
PhD student
ablood.at.som.llu.edu
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