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The following message was posted to: PharmPK
Dear All,
Could anyone send me information about articles that describe the
importance
of compartmental methods in Pharmacokinetics and the aplication of these
compartmental methods from predict steady-state from single dose.
Best Regards,
Daniel
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The following message was posted to: PharmPK
The text "Pharmacokinetics" by M. Gibaldi and D. Perrier (Marcel
Dekker, 1982) will be useful.
Sri Melethil
[You might try http://www.boomer.org/c/p1/ as well ;-) -db]
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The following message was posted to: PharmPK
Dear Daniel,
there is very extensive literature on the importance and relevance
of compartmental models. One book which I would recommend, for easy to
understand, practical compartmental PK modeling is, "Pharmacokinetics,
Principles and Applications", by Mehdi Boroujerdi. Kinetica, is a
widely used commercial software program for PK analysis, and has
built-in steady state models you can use right away. This is a great
way to actually get you to predict steady state parameters from a
single dose, based on compartmental methods, and somewhat learn the
science as you do so. You can download a free demo version of Kinetica
and get more information about it at:
http://www.innaphase.com/products_kinetica.html
Ravi Kuppuraj
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The following message was posted to: PharmPK
I suggest "The Rise and Fall of Compartmental Analysis", Pharmacological
Research, Vol. 44, pages 337-342 (2001).
[by Aldo Rescigno - db]
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Dear Daniel.
A 3rd Edition of the text "Pharmacokinetics" by M. Gibaldi and D.
Perrier (Marcel Dekker, 2003) is coming out soon (ISBN: 0-8247-0295-6).
This work provides the classic elaboration of pharmacokinetic
principles.
It is also the foundation upon which PK Solutions - the software that
makes pharmacokinetics easy - is based. A list of the equations found
in the text and used by PK Solutions is available free from our web
site at www.SummitPK.com
One thing to note, as exemplified by Gibaldi's approach, the term
"compartmental methods" does not necessarily imply the need for fitting
data to define "compartmental models." One can use exponential terms
(derived, for example, from curve stripping methods) to gain a robust
description of pharmacokinetic parameters without the assumption of a
specific compartmental model.
Regards,
David S. Farrier
Summit Research
www.SummitPK.com
DFarrier.aaa.SummitPK.com
David S. Farrier, Ph.D.Phone: 970-249-1389
Summit Research ServicesFax:: 970-249-1360
68911 Open Field Dr.Email: DFarrier.-at-.SummitPK.com
Montrose, CO 81401Web: http://www.SummitPK.com
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The following message was posted to: PharmPK
Daniel Rossi de Campos asked PharmPK:
Extensive information is available. I recommended that Daniel start
with two sources:
(1) Work written by the great toxicologist, Dr. Melvin Andersen and his
colleagues, particularly with Harvey Clewell, a brilliant programmer. I
enclosed contact information separately for Daniel's use only. In the
past,
Dr. Andersen has been very generous with his time in providing access
to this body of information. However, he is incredibly busy. Anyone in
the U.S, can search for publications by Andersen and Clewell through
the National Library of Medicine's Pub Med.
(2) Sections of Tony Cox's book on Risk Analysis, e.g. Subsection
3.1 of Chapter 2 "Compartmental Flow Simulation Models."
Daniel M. Byrd III, Ph.D., D.A.B.T.
Deputy Director
Life Sciences Research Office
9650 Rockville Pike
Bethesda, MD 20814-3998
(301)530-7034 phone
Please send responses and inquiries to my home email address:
vze2pnbq.at.verizon.net
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)