PharmPK Discussion - Content of UGT expression in liver

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On 4 Sep 2003 at 14:57:53, mas.kanou.aaa.teijin.co.jp sent the message


The following message was posted to: PharmPK

Hello!
I would like to know whether it is still unknown that the content
  of UGT (UDP-glucuronosyltransferase) expression in liver.

Your opinion will be greatly appreciated.

Masanobu Kanou
Metabolism and Pharmacokinetics Research Department
Pharmaceuticals Development Research Laboratories
Teijin Institute For Bio-Medical Research,Hino,Japan

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On 24 Sep 2003 at 09:00:37, Philip.Lienau.aaa.schering.de sent the message


The following message was posted to: PharmPK

dear Masanobu,

there is a very interesting article of Jiunn Lin and B. Wong you might
be
aware of:  "Complexities of Glucoronidation Affecting In Vitro - In Vivo
Extrapolation" Curr. Drug Met. 2002, 3, 623-646

best regards,

Philip

Dr. Philip Lienau
Schering AG
Research Pharmacokinetics

Tel.: +49 - 30 - 468 - 18507
Fax: +49 - 30 - 468 - 12238

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On 30 Sep 2003 at 11:17:56, mas.kanou.-at-.teijin.co.jp sent the message


The following message was posted to: PharmPK

Dear Philip

Thank you  for useful information.
It is the midst which orders reference now.
I want to clarify about isolation of in vitro in UGT, and in vivo.

with regards,

Masanobu

Masanobu Kanou
TEIJIN limited
Pharmaceucals Development Reserch Laboratories
TEL:+81-42-586-8248
FAX:+81-42-587-5518

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