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The following message was posted to: PharmPK
First, I'd like to thank everyone who responded to my
questions about the dosing suspension i.p.
In regards to toxicity of Cremophor in nude mice, we
have done up to 20 day daily i.p. with a
cremophor/ethanol/saline (1:1:4) formulation and we
have not seen toxicity with this vehicle. But
wild-type (immune competent) mice may react to the
vehicle differently than nudes.
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