PharmPK Discussion - CYP inhibition

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On 22 Sep 2003 at 10:40:55, Stipanicic Sinisa (Sinisa.Stipanicic.-a-.pliva.hr) sent the message


Hi,

I am working on a molecule which intended rout of administration is
intra nasal. IC50 for CYP 2D6is less than 5 uM. I am wondering if i.n.
administration implies less liability for drug-drug interaction, in
comparison to p.o. administration.

Thanks

Sinisa

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