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Im currently doing some easy research on the Dissolution profile of
Acetylsalicylic acid Tablet on Ugandan Market. There are two main
catergories of tablets Locally manufactured and imported products.
Do I need to carry out parametric/non parametric tests on the results?.
If yes under what conditions.
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> Im currently doing some easy research on the Dissolution profile of
> Acetylsalicylic acid Tablet on Ugandan Market. There are two main
> catergories of tablets Locally manufactured and imported products.
> Do I need to carry out parametric/non parametric tests on the results?.
> If yes under what conditions.
I guess, you are aimed at testing similarity of dissolution processes.
If so, and if you use appropriate sampling schedules, see for
example study (1), I would suggest to use the method for
modeling dissolution processes and the method for testing
similarity of dissolution process described in our recent
study (2). The latter method can also be employed to test similarity
of dissolution rates, as functions of time. This method is
compared with that based on the f2 factor (3).
1. Tod M, Rocchisani JM. Comput Methods Programs Biomed 1996; 50: 13-22
2. Dedík L, Durisová M. Comput Methods Programs Biomed 2002; 69:
49-55
3. Shah VP, Tsong Y, Sathe P, Liu J. Pharm Res 1998; 15: 889-896
Maria Durisova, PhD, DSc,
Head of Department of Pharmacokinetics
and Scientific Secretary
Institute of Experimental Pharmacology
Slovak Academy of Sciences
841 04 Bratislava 4
Slovak Republic
Phone/Fax: +421 2 54775928
http://www.uef.sav.sk/durisova.htm
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)