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Can DMSO be used for IV administration of a water insoluble drugs?
Please mention the references if you do have any.
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The following message was posted to: PharmPK
People use DMSO for iv injection, however not recommended as it may not
only increase the penetration of the test compound into many organs,
but also cause hemolysis. Try making an emulsion in Ringer's solution
containing cholic acid, L-a-phosphatidylcholine and corn oil, NaOH is
used to adjust pH. I have used it for iv administration of TCDD and
recently for another extremely lipophilic compound and found to be
stable for weeks when kept in refrigerator. The original reference for
this technique is:
Weber, L. W., Ernst, S. W., Stahl, B. U. and Rozman, K. (1993). Tissue
distribution and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin
in rats after intravenous injection. Fundam. Appl. Toxicol. 21:523-534.
Alternatively, people use EMULPHOR EL-620 (aka ALKAMULS EL-620) to
emulsify lipophilic materials for short period of time, it needs
vortexing right before filling syringe. Emulphor is actually
ethoxilated castor oil and water. To prepare emulsion lipophilic
material is dissolved in ethanol and then mix with emulphor.
I personally like to use the first method of making stable emulsion
described by Weber et al. There are some specific steps in making this
emulsion which you can not extract from the paper. Contac me if you
need the protocol for making it.
Shakil A. Saghir, M.S.P.H., Ph.D.
Senior Research Toxicologist
The Dow Chemical Co.
1803 Bldg., Midland, MI 48674
Phone: (989) 636-8708, Fax: (989) 638-9863
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