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The following message was posted to: PharmPK
I am performing some studies refered to an antiviral drug, in which I am
analyzing its permeation across intestinal sacs using the in vitro
everted
sac techniques. The point is that I have perfomed this techniques using
sections of jejunum and ileum and using diferent concentratinos of drug
I
have found that plotin the permeation constant vs the concentration the
plot is not linear when analyzing jejunum (fact that appears to be due
to
an active transport or something like that), while in the ileum this
plot
is linear. My question is how a I supposed to identify the phenomena
that
is present in the jejunum.
Thank you very much
Lic. Mario Alfredo Quevedo
Dpto. de Farmacia
Facultad de Ciencias Quimi~cas
Ciudad Universitaria
T.E./Fax: 54-351-4334163
Ciudad Universitaria
C.P. 5000 Cordoba - Argentina
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