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I'm trying to simultaneously fit data for parent & metabolite plasma
levels, considering the hepatic first pass.
Because I was not able to write the code for model in WNL, I used the
designer tool from Kinetica.
I have considered that from absorption compartment, the parent is both
absorbed in central compartment (1st order) and metabolized to
metabolite (MM). Even if the administration was oral, solid
pharmaceutical form, I have considered an "like IV bolus"
administration of drug in absorption compartment (I think in that mode
I will loose only lag time calculation)
After fitting, some parameters (kel for parent and metab) are close to
values obtained by fitting to simple bicomp model, but another
parameters donít (k inter comp)
The plasma levels for Parent drug and Metabolite (pmol/ml, mean of 36
values) , the model "picture" and the fit are in the next link:
Is possible to translate the code in WNL? Does the model is correct?
Can be included lag time in model?
I will appreciate any comments or suggestions!
Sorry for my English.
Pharm. Chem. Vlase Laurian
Dept. Pharm. Technol. & Biopharmaceutics
Faculty of Pharmacy
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