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The following message was posted to: PharmPK
Hi All,
Can anybody suggest me suitable dissolution medium for Glipizide,
poorly soluble weakly acidic drug. For, inspite of suggestions to
use pH 7.4 buffer, I found its solubility is fairly low to meet
sink conditions. And, if I continue to use the same, I am afraid I
might get poor invitro-invivo correlations.
I would appreciate your help in this regard
Thanks
Gerald
Thankfuly Yours ...
Maria Gerald Rajan,
University of Tennessee, H.S.C.,
214, Feurt Bldg,
26, S. Dunlap St.,
Memphis,
TN-38163
U.S.A.
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Dear maria
Glipizide is poorly soluble and good bioavailable drug,you may do that
do comparision with innovator in diiffrent media and calculate F1 &
F2,then there will not a problem to you.
jagadeesh t
NDDS
Zydus research Centre
Ahmadabad INDIA
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