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hi all
i am working on a herbal preparation and its pharmacokinetics in rats.
I am having a crude standardized preparation (on basis of two markers)
wherein we are able to monitor signals for few additional components.
We have pure standards for two marker components only and have a
LC-MS/MS method for quantiation as well.
The query is that if i perform oral pharmacokinetic study using crude
mixture, then i can get concentration Vs time data for all components.
Now i have two set of data , one for which absolute concentration is
available and pharmacokinetic parameters can be calcultaed. Second data
set contains relative concentration-time only. Can we extract some
pharmacokinetic information from second data set? IF yes then how this
can be done and how appropriate and reliable it is
i hope i have made myself clear about the problem.
thanks in advance
Vipul Kumar
vipul kumar gupta
Pharmacokinetics and
Metabolism Div.
CDRI, LUCKNOW-226001
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HI vipul
You have an interesting query and the main problem which I understood
is the lack of pure standards you have. It is is very difficult to say
much about this problem as of now but definately for the components in
which you are ploting relative concentration vs time plot you can
predict the dose independent parameters like K or beta, elimination
half life in which you dont require the exact dose of the component
which is administered as a mixture.The other parameters like Cl, Vd AUC
which are dependent on dose is difficult to talk about with this kind
of information.
I hope this help
Regards
Nitin
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The following message was posted to: PharmPK
Hi, Nitin,
I agreed with you on the selection of dose independent paprameters for
a set
of relative concentration data. But I want ask a question on
reliability.
Since more than 1 data for kinetic parameters, eg. half-life time, were
obtained, which one would be most reliable to evaluate the crude herbal
medicine. Do you have any comments?
Karen
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