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The following message was posted to: PharmPK
Dear all,
I am stuyding a series of compounds which have very low log D values ~
0.4 but give very high clearance and volume of distribution in rats. In
vitro studies with human liver microsomes indicate that they are
metabolically stable. The compounds have a polar COOH group and I think
it is possible that they undergo Phase II metabolism and are excreted
into the bile, which could be a possible explanation for the fast
clearance. However, I am not very sure why they show such high Vd
(almost 4 L) given that they are very polar. Can anyone please suggest
the possible reasons for the high clearance and Vd. Thanks a lot.
-Saileta
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The following message was posted to: PharmPK
Dear:
In the case that we should consider entero-hepatic circulation,
intestinal
lumen could also
become a distibution tisseu.
Teruaki Okuda, Ph.D.
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