Back to the Top
The following message was posted to: PharmPK
Hello everybody,
I have a problem in understanding the difference between two elimination
rate constants in two compartment models: k (elimination rate constant
from
central compartment) and hybrid constant b (beta). Which one (if any) is
influenced by distribution? Could somebody explain that to me?
Also, what is the meaning of Vss (in two compartment models) after a
single
dose?
Thanks a lot.
Anita
Back to the Top
The following message was posted to: PharmPK
On 6/26/03 14:47, "Rakic Anita"wrote:
In a two-compartment model there are two elimination constants, one
from the
first and one from the second compartment; the elimination from the
sampled
compartment is described by a curve whose final slope approaches the
slowest
of the above elimination constants. But if those two elimination
constants
are not sufficiently different one from the other, the observed slope
reaches its final value very slowly and it is very difficult to observe
it.
Moreover, in real life it is very rare to find two compartments obeying
the
rules we find in textbooks.
An explanation of the Vss requires some drawings and formulas that this
ML
does not support; I could send it directly to you on PDF format if you
like.
Aldo
[Aldo and others, I'd be happy to post 'drawings and formulas', etc to
the website here and link to this or your own website if you prefer -
db]
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)