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Dear friends.
I am doing pk profile of different drugs (with similar structures) in
plasma after single i.v. bolus injection. I am having very consistant
results with all of them but with a couple I have a really small
volumen of distribution (less than the blood volumen in mice). What can
be the cause?
Thank you for your imput
J
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The following message was posted to: PharmPK
The drug could be trapped in the plasma compartment or the RBC. Look
up Taxol if you are interested.
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The following message was posted to: PharmPK
What if the volume of distribution is smaller than
volume of plasma. What is the explanation then?
Rostam
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