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Hello everyone,
The discussions are so helpful to me in the area of Pharmacokinetics.
Could any one tell me, what is the maximum dosage of drug that one can
give as I.V. to rat and mice per kg weight for a single dose PK/PD
study ? Similarly, what is the maximum dose if given orally ?
Thanks !
Sreekanth Gutala
sgutala.-a-.hotmail.com
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The following message was posted to: PharmPK
Dear Sreekanth Gutala,
What i understand from your question is mg/kg dose of drug.
Which drug are you talking about, as far as i know there is no
general standardized rule for the dosage to be given in different
routes. It entirely depends on the LD50 of the drug. Different
drugs will have different LD50's with different route for
different animals. Your maximum dose should be much much less than
the LD50 of that particular drug. Hope it clarifies your doubt.
Regards,
B.L.Suresh
[LD50 - how about ED50? or was the question simply the maximum volume
of accompanying fluid that could be injected. I don't have a good feel
for maximum bolus volume but an infusion could allow significant
volumes - db]
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The following message was posted to: PharmPK
If you are referring to dosing volume, for the IV dose the dosing
volume will depend on the vehicle in rodents. If it is saline (or
water for injection, if you get precipitation of the drug as it is
administered IV in saline) you may administer 1 ml/kg as a bolus shot,
followed by flushing in with enough of the vehicle to cover the dead
space. For organic solvents like diluted DMSO you will have to
administer a volume and concentration which will not cause any
hemolysis of the blood. For PO dosing you may go for 5-10 ml/kg,
subject to a maximum dosing volume of 2 ml in rats and 0.5 ml in mice.
Hope this helps.
Ananda
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The following message was posted to: PharmPK
Dear Sreekanth Gutala,
If you are looking for the maximum dosage volume then you can
refer to this particular article where they have give in detail
about the volumes completely.
"A Good Practice Guide to the Administration of Substances and
Removal of Blood Including Routes and Volumes" Journal of Applied
Toxicology 21, 15-23 (2001), by David Smith and group.
I belive this topic has already been discussed previously.
Regards,
B.L.Suresh
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