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The following message was posted to: PharmPK
I am doing pharmacokinetics of a drug A after its oral
and iv dose. I am monitoring drug and its metabolite
B in biological fluids simultaneously. When I fitted
the plasma concentration time profile of the
metabolite after oral administration it is best
fitting to one compartment open model while the C-t
profile of B after iv administration best fits to two
compartment open model. The drug B is known to follow
two compartment when given alone as the main drug.
What could be the possible reasons for this.
[You will only see 'all' the exponentials if they are sufficiently
different OR you fit the IV and PO (or A and B) data simultaneously -
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