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In my former hospital, a regional hospital in a rural area in the
Netherlands, "once daily" was "once daily" with far less than 5%
exceptions. In any other depatment than ICU or neonatal care different
regimens (q36h was the largest dosing interval)were not applicable.
We sampled 2h and 8h (6-10) after the start of the first 30min infusion
of 6mg/kg in 100ml. The exact times were reported within a limit of
5min. If a patient didn't reach a trough level <1mg/l, a different
antibiotic was considered indicated!
This sample regimen was chosen, because in this way we could garantee
analysis before the secons dose and because the 6-10h value could be
detemined with more accuracy than a real minimum.
The results were fitted in an pharmacokinetic programme. The obtained
curve and the comments were delivered at the ward, to show the nursing
staff the result of their good work and to have it added to the patient
file before the next round.
Hugo Gudde, ziekenhuisapotheker
VieCuri Medisch Centrum,
Tegelseweg 210 postbus 1926
5912 BL VENLO 5900 BX
tel: +3177 3205187
fax: +3177 3206001
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Copyright 1995-2010 David W. A. Bourne (firstname.lastname@example.org)