Back to the Top
Dear all
I am involved in conducting permeability experiments on drugs using
caco-2 cells. I would be thankful if any one of you could help in
knowing how to do the actual calculations in determining the drug
movement from A-B (apical to basal) and especially B-A (basal to
apical) compartments. Can we calculate the flux of both A-B and B-A ion
the same caco-2 cell plate.
Regards
Tausif Ahmed
Doctorate student,
Dept. of Pharmaceutical Medicine
Ranbaxy Clinical Pharmacology Unit
Majeedia Hospital,
Hamdard University, New Delhi,
India
Back to the Top
Dear Tausif,
Please find below the important reference, which will help in
calaculation of Papp.
Artursson P. (1990) J. Pharma. Sci. 79(6):476-482
Artursson P and Magnusson C. (1990) J. Pharma. Sci. 79(7):595-600
Yee S. (1997) Pharm. Res. 14(6) :763-766.
Garberg P, Eriksson P, Schpper N, Sjostrom B. (1999) Pharm. Res. 16(3):
441-445
Samiulla
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)