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Dear Norman,
One possibility is the requirement of fast delivery to the site of
action
which you achieve iv but no po. For example, you would not expect an iv
anaesthetic like thiopentone or propafenone to work by mouth because you
just would not get enough to the brain in time even if it were wholly
absorbed by mouth. One reason for this would be the relatively short
duration of action because after an oral dose the drug has gone from the
receptor by the time more arrives. You might possibly see an attenuated
effect of an iv anaesthetic given po as mild sedation so I wonder if
that
could apply in your case.
Regards
Andrew Sutton
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