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All,
I am looking for some information on building models for extended and
sustained release oral formulation. What kind of
approximations/assumptions are possible if one were to extend a normal
absorption oral profile/model for this -- any pointers will be
appreciated.
Ravi Kuppuraj
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The following message was posted to: PharmPK
The physiology based PK-simulation software PK-Sim(R) is ideally suited
for this
purpose. It integrates the simultion of oral absorption with a whole
body
PBPK-model. Absorption can be simulated for immediate release
formulations as
well as for such with sustained release characteristics using different
predefined release functions or a tabularized function, e.g. from
experimental
release data. The possibility to regard explicitely active transport in
the gut
(and all organs), first pass metabolism and enterohepatic circulation
enables
modeling of absorption of different kinds of application forms in great
detail.
See: www.pk-sim.com
Walter Schmitt
Bayer Technology Services GmbH
PT-AS-Biophysics
Tel.: +49(0)2173/38-4546
Fax: +49(0)2173/38-9694546
E-Mail: walter.schmitt.ws.aaa.bayertechnology.com
Internet : http://www.bayertechnology.com
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