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Hello all,
Would anyone care to suggest how one might determine the pKa (or pKb)
of weakly acidic/basic NCEs? Can one titrate a micromolar solution?
Are there any useful programmes that predict pKa from structure?
I think we all agree it is very useful to know the pKa but...
Thanks
Bill O'Neil
Senior Research Scientist, Pharmacokinetics
Xenon Genetics Inc.
3650 Gilmore Way
Burnaby, BC
V5G 4W8
604 484 3300 ext 142
[I like spectrophotometric methods - are spectra in different pH
solutions different? :-) - db]
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Bill,
A good pKa calculating program is available
fromwww.ap-algorithms.com/ionization.htm
Alanas
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