PharmPK Discussion - Plasma assay for Simvastatin and Lovastatin

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On 29 Nov 2003 at 04:46:47, Jimmy Coulton (jimmy_coulton.aaa.yahoo.com) sent the message


Hi all,
I would be grateful if anyone can send by e-mail (or post on the web)
details of a recent (2002/2003) HPLC/UV method for assay in plasma of
Simvastatin and Lovastatin. We don't have use of an
HPLC/MS, but  need to carry out bioequivalance studies on newer
formulations.  Details of sample preparation, extraction, column
details etc would be highly appreciated.

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On 1 Dec 2003 at 12:17:46, "satyawan jadhav" (satyawanjadhav.-at-.rediffmail.com) sent the message


hi Jimmy,
Following are some of the references u may be interested in,

1. Determination of simvastatin in human plasma by high performance
liquid chromatography.   Se Pu. 2000 May;18(3):232-4

2.Simultaneous determination of simvastatin and its hydroxy acid form
in human plasma by high-performance liquid chromatography with UV
detection.J Pharm Biomed Anal. 1992 Sep;10(9):693-7

3.Determination of lovastatin in human plasma using reverse-phase
high-performance liquid chromatography with UV detection.  Ther Drug
Monit. 2000 Dec;22(6):737-41.

But the major concern to me is that I was not able to reproduce any of
these methods, specially recovery point of view.

Any suggestions in this regrad are welcome.

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