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I would just wondering if you checked out the possibility that your
drug is a P-glycoprotein substrate, in which case it can be effluxed
within the intestine, and reduced bioavailability would be observed.
This possibility can easily be tested using cell lines, or can be
predicted by examining the chemical structure of the drug. If you
would like more information, please let me know.
Apotex Research Inc.
Biometrics Unit, Biomedical Division
Phone: (416) 749-9300 (EXT 8698)
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