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Here is a question for the membership:
1) Are there known species differences between renal clearance of
smaller proteins? In particular, I am concerned about mouse versus man
for antibody fragments having MW values between 25 kDa and 80 kDa. Our
data suggests that mice have significantly shorter mean residence times
than patients for such fragments. Our antibody fragments are labeled
with either radioiodines or In-111.
2) I have also heard that mice excrete albumin via the kidneys - unlike
normal patients. Is that true?
Any advice or references would be appreciated.
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