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The following message was posted to: PharmPK
You can find out information about simultaneous fitting plasma and urine
data by contacting the SAAM Institute, Inc
(info.aaa.saam.com; www.saam.com), and asking for the case study on inulin
kinetics. There are different ways in which such data can be
analyzed some of which require a delay in the appearance in plasma of
administered drug. You can describe:
- individual urine collection,
- cumulative urine collections, and
- rate of excreation.
Cumulative and individual urine contain slightly different kinds of
information, even though the individuals are
added up to give the cumulative.
For example, if a subject missed a collection, this will show up when
model the individual collections; obviously
all cumulative data from that point forward will be erroneous because
missed collection. As another example,
the subject could be slightly off in two collections. For example, one
be 18 hours and the other 36 hours instead
of every 24. This also will show up when you jmodel the individual
collections. In this case, however, the cumulative will,
in the end, be okay.
Simultaneous fitting of data is extremely easy using the SAAM II
system. SAAM II, originally developed
at the University of Washington, is now distributed by the SAAM
Inc. The SAAM Institute sponsors modeling
workshops where plasma and urine data are specifically addressed.
David Foster, PhD, CEO
SAAM Institute, Inc.
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Copyright 1995-2010 David W. A. Bourne (email@example.com)