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The following message was posted to: PharmPK
The LifeLine Group is making available a software program that captures
correlations between physiological factors used in PBPK models. The
software "Physiological Parameters for PBPK Modeling" or P3M, can now be
downloaded with out charge from The LifeLine Group's web page:
The parameters investigated in this project include: 1) volumes of 22
and tissues; 2) blood flows for the organs and tissues; and 3) the total
cardiac output under resting conditions, 4) total body surface area,
average daily inhalation rate. These parameters are expressed as
correlated values for the approximately 30,000 individuals evaluated in
NHANES III survey. These records provide a source of data for human
physiological parameters where 1) the parameter values for an individual
record are correlated with one another, and 2) values of parameters
interindividual variation in populations of a specific gender, race,
P3M allows records to be retrieved randomly from the database (with
replacement) for individuals of a specific age, sex, and ethnicity.
The basis for the software is described in a journal article "Modeling
Inter-individual Variation in Physiological Factors Used
in PBPK Models of Humans Paul S. Price, Rory B. Conolly, Christine F.
Chaisson, Elizabeth A. Gross, John S. Young, Eric T. Mathis, Douglas R.
Tedder" that has been accepted for publication by Critical Reviews in
Toxicology. Please contact me if you would like a preprint the article
if you have need for any additional information.
Paul S. Price, Director
The LifeLine Group
129 Oakhurst Rd.
Cape Elizabeth, ME 04107
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Copyright 1995-2010 David W. A. Bourne (firstname.lastname@example.org)