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The following message was posted to: PharmPK
Hello everyone,
What is the most appropriate statistical test (ANOVA or power model)to
assess
dose proportionality in drug development(to compare pk parameters for 2
or more
doses).
Thanks
Samia
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The power model/confidence interval approach is pragmatic and has
advantages over common older methods. See
See BP Smith, et al. Confidence Interval Criteria for Assessment of
Dose Proportionality. Pharm Res 2000;17(10):1278-1283
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The following message was posted to: PharmPK
Samia:
A detailed discussion regarding Dose Proportionality can be found in
Kevin
Gough et al Drug Information Journal 1995, 299(3) 1039-49.
Hope this helps.
Prasad NV Tata, M.Pharm., Ph.D.
Manager-Pharmacokinetics
Mallinckrodt, Inc.
675 McDonnell Blvd.
Saint Louis, MO 63134-5840
Tel: (314) 654-5325
Fax: (314) 654-9325
e-mail: prasad.tata.at.tycohealthcare.com
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