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Dear colleagues,
Would be highly appreciated if some of you could provide some
information to find out what is the absolute bioavailabilty of
tolbutamide.
Thanks in advance.
All the best.
Eric Helmer
Johnson and Johnson Pharmaceutical Research and Development
Drug Evaluation Clinical Pharmacokinetics
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The following message was posted to: PharmPK
EFFECTS OF FOOD: none (Prod Info tolbutamide, 1997; Antal et al, 1982).
Administration of tolbutamide 30 minutes before meals may result in
better
blood glucose control after the meal (Ferner & Chaplin, 1987; Samanta
et al,
1984).
Antal EJ, Gillespie WR, Phillips JP et al: The effect of food on the
bioavailability and pharmacodynamics of tolbutamide in diabetic
patients.
Eur J Clin Pharmacol 1982; 22:459-462.
Ferner RE & Chaplin S: The relationship between the pharmacokinetics and
pharmacodynamic effects of oral hypoglycemic drugs. Clin Pharmacokinet
1987;
12:379-401.
Samanta A, Jones GR, Burden AC et al: Improved effect of tolbutamide
when
given before food in patients on long-term therapy. Br J Clin Pharmacol
1984; 18:647-648.
Hope this helps,
Mike
Michael A.Jones, Pharm.D.
Scientific Editor
Integrated Content/Clinical Decision Support
Thomson Healthcare, Inc.
6200 S. Syracuse Way #300
Greenwood Village, CO 80111-4740
(303) 486-6723
1-800-525-9083 ext. 6723
mike.jones.at.mdx.com
www.micromedex.com/mlm.htm
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