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The following message was posted to: PharmPK
In July 2003 the LifeLine Group announced the availability of a software
program ("Physiological Parameters for PBPK Modeling" or P3M) that
captures
the correlations between physiological factors used in many exposure and
PBPK models. Recently a user identified an error in the data. This
error
has been corrected and the revised version P3M Version 1.01 is
available for
downloading at our web page:
http://www.thelifelinegroup.org
The original version (1.00) should not be used.
The parameters included in P3M Version 1.01 include: 1) volumes of 22
organs
and tissues; 2) blood flows for the organs and tissues; and 3) the total
cardiac output under resting conditions, 4) total body surface area,
and 5)
average daily inhalation rate. These parameters are expressed as
records of
correlated values for the approximately 30,000 individuals evaluated in
the
NHANES III survey. These records provide a source of data for human
physiological parameters where 1) the parameter values for an individual
record are correlated with one another, and 2) values of parameters
capture
interindividual variation in populations of a specific gender, race,
and age
range.
The basis for the software is described in the journal article:
P. S. Price, Conolly, R.B., Chaisson, C.F., Young, J.S., Mathis E.T.,
Tedder
D.T. 2003. Modeling Inter-individual Variation in Physiological Factors
Used
in PBPK Models of Humans, Critical Reviews in Toxicology Vol. 33, (5):
469-503
Paul S. Price, Director
The LifeLine Group
129 Oakhurst Rd.
Cape Elizabeth, ME 04107
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)