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Dear All,
I would like to know the optimum/maximum volume of drug solution that
can be administered by oral and iv routes to mice/rats/dogs/monkeys.
Pls let me know the references if any that could help me.
Thanks in advance
Naveen Sharma.
PK-NCER, Lupin Reseach Park, Pune, India
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The following message was posted to: PharmPK
Some guidelines can be found summarised online e.g.
http://advs.usu.edu/LARC/volgdco.htm
You should double check with your local animal care specialists.
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Investigator
Drug Metabolism, PCS, PPD, GPRD, Abbott Laboratories, Chicago, USA
Bernard.Murray.-at-.abbott.com
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The following message was posted to: PharmPK
Naveen,
A EFPIA/ECVAM paper on good practice in administration of substances
and removal of blood by Karl-Heinz Diehl et.al. appeared in the
Journal of Applied Toxicology, 21(1),15-23, 2001.
Hope this helps
Sunil
Sunil S. Iyer
Department of Pharmaceutics
PO Box 980533
Virginia Commonwealth University-School of Pharmacy
410 North 12th Street
Richmond, VA 23298-0533
Ph: (804) 8286214
e-mail: iyerss.-at-.vcu.edu
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