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The following message was posted to: PharmPK
Dear Colleagues,
Usually Vss is expected to be higher in pregnant
animals (although may not be true depending on the
compound). I have seen 35-times higher Vss in pregnant
rats (and 20-times higher Cl) compared to non-pregnant
rats? Dose this make sense to anyone? Have you seen
these magnitudes of differences in your experiments?
Rostam
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