Back to the Top
I would like to know the drugs which are having absorption in stomach
or in duodenum. This information is helpful for my research.
Thanks and Regards,
Dear Mr.KalaBack to the Top
The stomach does not play a major role in absorbing drugs, even those
that are acidic and thus unionized and lipid-soluble at gastric pH,
because its surface area is much smaller than that of the small
intestine and gastric emptying is speedy (t1/2= 30 minutes)
But theoretically if pH- partition hypothesis is considered, acids in
the pKa range 2.5 to 7.5 are greatly affected by changes in pH and
therefore their absorption is pH -dependent. E.g. several NSAIDS like
aspirin, ibuprofen, phenylbutazone and penicillin analogs like
cloxacillin. Such drugs are better absorbed from acidic conditions of
stomach (pH < pKa) where they largely exist in unionized form.
Quoting kala_kotipalli.at.rediffmail.com:Back to the Top
Ciprofloxacin HCL , Metformin HCL are the drugs having absorption
window in stomach and Proximal intestinal areas in particular.
RANBAXY RESEARCH LABORATORIES.
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (email@example.com)