PharmPK Discussion - Absorption from the stomach and duodenum

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On 9 Apr 2004 at 09:07:28, "kala kotipalli" (kala_kotipalli.-at-.rediffmail.com) sent the message


Dear Members,
I would like to know the drugs which are having absorption in stomach
or in duodenum.  This information is helpful for my research.
Thanks and Regards,
kala

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On 11 Apr 2004 at 05:11:34, "sajjad desai" (drsdesai.-a-.rediffmail.com) sent the message

Dear Mr.Kala
The stomach does not play a major role in absorbing drugs, even those
that are acidic and thus unionized and lipid-soluble at gastric pH,
because its surface area is much smaller than that of the small
intestine and gastric emptying is speedy (t1/2= 30 minutes)
But theoretically if pH- partition hypothesis is considered, acids in
the pKa range 2.5 to 7.5 are greatly affected by changes in pH and
therefore their absorption is pH -dependent. E.g. several NSAIDS like
aspirin, ibuprofen, phenylbutazone and penicillin analogs like
cloxacillin. Such drugs are better absorbed from acidic conditions of
stomach (pH < pKa) where they largely exist in unionized form.
Regards
DR.S.A.Desai
APL-Research center

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On 11 Apr 2004 at 21:46:36, b pradeep (pradeepbhadauria.-at-.sify.com) sent the message

Quoting  kala_kotipalli.at.rediffmail.com:
Ciprofloxacin HCL , Metformin HCL are the drugs having absorption
window in stomach and Proximal intestinal areas in particular.
Regards,
Pradeep Bhadauria
RANBAXY RESEARCH LABORATORIES.

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