Back to the Top
Dear all,
it is well known that HSA has a number of binding sites and two of them
(Sudlow's sites) are more "important" than the others.
It seems to me that some drugs (ie aspirin) show a preferred
binding site but are also able to bind to the other. Do you know papers
on this topic besides Peter's book "All about albumin"?
Many thanks
Giulia Caron
Back to the Top
Drugs are bound on site I (The warfarin site according to Sudlow) or
site II
(the diazepam site); or on both. you can see some exemples in these
ref:
F.Bree et al Fund.Clin. Pharmacol. 2002
S. Urien et al Biochem Pharmacol.1994
F.Bree et al Biochem Pharmacol 1989
F.BREE
BIOPREDIC
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)