Dear all,Back to the Top
For proceeding in Invitro In vivo correlation for a formulation of
Ibuprofen, I need to know the class of Biopharmaceutical classificaiton
system in which Ibuprofen may belong.
I searched the internet, but couldnt find any relevant material.
If anyone can suggest some means of finding this information, It would
be of great help to me.
Thanks in advance,
Dear Vardhini,Back to the Top
As i know Ibuprofen is in Class 2 , as ketoprofen and flurbiprofen.
Hope this helps you,
DearBack to the Top
Ibuprofen is Class 2.
e.g. in Article: Molecular Properties of WHO Essential Drugs and
VOL. XXXX NO. XXXX ( before NO.1, VOL1.) MOLECULAR PHARMACEUTICS
Dear All,Back to the Top
I need to know the BCS class for following Drug substances:
* diclophenac sodium
Do you know where can I find the BCS system for drugs through internet?
Many thanks in advance for your help
Dear Parvin,Back to the Top
You can find some of them in:
Kasim, et al, 2004. Molecular Properties of WHO Essential Drus and
PRovisional Biopharmaceutical Classification. Molecular pharmaceutics,
It's a great and complete article and you can find it in the web.
Parvin,Back to the Top
Regarding your query, the following reference might be of help:
Nehal A. Kasim, Marc Whitehouse, Chandrasekharan Ramachandran, Marival
Bermejo, Hans Lennernas, Ajaz S. Hussain, Hans E. Junginger, Salomon
A. Stavchansky, Kamal K. Midha, Vinod P. Shah, and Gordon L. Amidon;
"Molecular Properties of WHO Essential Drugs and Provisional
Biopharmaceutical Classification"; Molecular Pharmaceutics, 2004
January/February, Vol 1(1), 85-96.
Sunil S. Iyer, M.Pharm.
Department of Pharmaceutics
Virginia Commonwealth University - School of Pharmacy
PO Box 980533
410 North 12th Street
Richmond, VA 23298-0533
Phone: (804) 828-6214
Fax: (804) 828-8359
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This is a general answer to all of the BCS related studies
If you can carry out the solubility study (highest dose in 250 ml with
ph 1 to 8) you will get the idea of BCS solubility but as far as
Permeability is concerned you may have to collect following information
such as Pka, Log P, Partition coefficient, and some preliminary in situ
studies if at all you are planning for experimental work or else you
can refer out Prof. Hans Juninger in Netherlands, he as got a good
collection of all this information ....you can refer him at Laden
Novel Drug Delivery Systems
Glenmark Research Center
PharmPK Discussion List Archive Index page
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