Reply to Paula Macedo CerqueiraBack to the Top
Re: Amiodarone forming micelles
Thanks Paula. It could be a particularly interesting example if there
are differences between formulations of Amiodarone whenboth are given
in the fed state. If formulation makes little difference then we won\0xEDt
have to do the BE/fed study every time the formulation is tweaked.
I imagine that micellar forms are rather unstable and could for example
behave differently depending on the fat content of the meal or gastric
acidity, so I would be very interested to know whether they have a
bigger impact than formulation on them.
Does the discussion of the paper have an opinion on that?
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