Back to the Top
Dear Dr. Cerqueira and colleagues;
Based only on the molecular structure. Amiodarone may be in the
hydrotrope class, which self-associate in a way similar to, but
different from, from micelles.(Buurma, Niklass Jan, Doctoral thesis
'Water, a Unique Medium for Organic Reactions', February 2003,
Universtiy of Groningen, [an On Line Resource]; Srinivas, V.; Rodley,
G. A.; Ravikumar, K.; Robinson, W. T.; Turnbull, M. M.;
Balasubramanian, D.Langmuir1997, 13, 3235).
Hydrotropes may also interact with surfactants, such as bile salts, to
form yet other kinds of associations, such as "wormlike micelles".
(Hassan, P.A.; Raghavan, S. R.; Kales, E.W.;Langmuir2002, 18,
2543-2548)
Frank
Frank Bales, Ph.D.
Senior Regulatory Consultant
Worldwide Regulatory Affairs
PAREXEL Intl.
2520 Meridian Pkwy, Suite 200
Durham, NC27713
(508) 650-8051Phone
Email:frank.bales.aaa.parexel.com
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)