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The following message was posted to: PharmPK
I am looking for information about the lipophilicity of beta-blockers.
Specifically, I should like to know:
1. What the octanol:water partition coefficients are for as many
beta-blockers as possible.
2. How good the correlation is between the octanol:water partition
coefficients and the brain penetration of these drugs.
3. Whether there are any other good/better measures of brain
Dr J K Aronson
University Department of Clinical Pharmacology
Oxford OX2 6HE
Tel: +44 (0) 1865 224626
Fax: +44 (0) 1865 791712
Mobile: 0781 373 8696
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