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I work in the ADME part on drug development. In pre-PK animal studies my
company are trying to reduce the number of animals (rats) used and also
the variability between the different animals.
The way we are exploring consist on cannulated rats. After the
intervention we perform the administration and then we began to take
blood samples at different times (approx. 0.4 ml for each time point, and
3 or 4 points in total).
In order to preserve the volimie in rat, we reintroduce saline solution
after every extraction point. But we have some questions in internal
1) Is ethically correct this way of working?
2) Are the pharmacokinetic parameters (calculated from the results
obtained by this method) real?
3) Someone works in this way,?..or similar?
Thanks in advance for your time!!
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