Dear all,Back to the Top
Does anyone know of published studies on the pharmacokinetics of caffeine?
Has any compartmental modeling been applied to the time-course of caffeine
plasma concentrations? I am interested in "simple" things like
dose-linearity, estimates of different PK parameters, and variability
issues after po doses.
Dr. Gordi,Back to the Top
You can use the following paper written by Terziivanov
et al. Nonparametric expectation maximisation (NPEM)
population pharmacokinetic analysis of caffeine
disposition from sparse data in adult Caucasians.
Systemic caffeine clearance as a biomarker of
cytochrome P450 1A2 activity. Clin Pharmacokinet
I can forward the paper as a PDF file.
Simply use "Caffeine [ti] AND pharmacokinetics [ti]" in the searchBack to the Top
window for Entrez PubMed and you will get a lot of references - Quite a
few are to do with population PK.
But see following specifically re neonates (from our own team):-
Lee T, Charles B, Steer P, Flenady V. Population pharmacokinetics of
intravenous caffeine in infants with apnea of prematurity. Clin
Pharmacol Ther 61, 628-640, 1997.
Lee TC, Charles BG, Steer, PA, Flenady, V. Salivary-serum monitoring of
caffeine following intravenous administration for apnoea of prematurity.
Ther Drug Monit 18, 288-293, 1996.
Bruce CHARLES, PhD
Associate Professor and Director,
Australian Centre for Paediatric Pharmacokinetics
School of Pharmacy
The University of Queensland, 4072 Australia
[University Provider Number: 00025B]
TEL: +61 7 336 53194
FAX: +61 7 336 51688
As far as I know there are some articles on the PK of caffeine in neonates ,forBack to the Top
Pop-Pk of caffeine in preamture neonates, Falcao et al. Eur J Clin Pharmacology
1997, 52: 211-217
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