Dear All,Back to the Top
We have calculated the PK parameters of a solvent after topical
application,
we know that the permissible daily
exposure (PDE) limit to the solvent is 50 mg. How do we calculate the
actual exposure in mg from our PK data?
Thanks for the help!
Juan He
juan.he.-at-.biovail.com
Juan HeBack to the Topwrote:
"...
We have calculated the PK parameters of a solvent after topical
application,[...] How do we calculate the actual exposure in mg from
our PK data? ..."
Juan:
You may want to look in the U.S. EPA: Risk Assessment Guidance for
Superfund (RAGS), Volume I: Human Health Evaluation Manual (Part E,
Supplemental Guidance for Dermal Risk Assessment). Available on
Internet: http://www.epa.gov/superfund/programs/risk/ragse/index.htm
You will find there standard methodology for calculation of dermal
intake and all relevant references.
Best wishes.
Janusz Z. Byczkowski, Ph.D.,D.Sc.,D.A.B.T.
Consultant
212 N. Central Ave.
Fairborn, OH 45324
voice (937)878-5531
e-mail januszb.-at-.AOL.com
homepage: http://members.aol.com/JanuszB/index.html
JZB Consulting web site: http://members.aol.com/JanuszB/consult.htm
Juan,Back to the Top
Janusz Byczkowski wrote you:
""We have calculated the PK parameters of a solvent after topical
application,[...] How do we calculate the actual exposure in mg from
our PK data? ..."
You may want to look in the U.S. EPA: Risk Assessment Guidance for
Superfund (RAGS), Volume I: Human Health Evaluation Manual (Part E,
Supplemental Guidance for Dermal Risk Assessment). Available on
Internet: http://www.epa.gov/superfund/programs/risk/ragse/index.htm
You will find there standard methodology for calculation of dermal
intake and all relevant references."
To me, Janusz is only partially correct. Volume 1 of RAGS is not
current
about the different definitions of dose and exposure, especially those
defined by Wayne Ott and his coworkers at Stanford. I can send you
the relevant citations, if you wish. Ott's views have some strong
advantages. Thus, I would recommend Ott's definitions and metrics,
but the (sometimes implied) RAGS methods.
Dan
Daniel M. Byrd III, Ph.D., D.A.B.T.
McLean, VA 22102
byrdd.at.cox.net
Dan:Back to the Top
Your comment is very interesting.
I would love to see the additional references.
The RAGS Part E, indeed dated September 2001, was prepared and peer
reviewed in 1998. Actually, it is a draft, published by EPA for public
comments and feedback, but it contains a lot of useful information.
I hope that you have submitted them your comments by the long passed
due date (beginning of 2002, but I still did not see their response).
Best wishes.
Janusz Z. Byczkowski
Dan,Back to the Top
Similarly, I found your comment very interesting and
would like to see those references. Would you please
forward them to me.
Thanks
Rostam
[Maybe the citations could be forwarded to the list - db]
TO: Pharm PKBack to the Top
Several contributors asked for the citations I referenced in my
previous note (06/23/04). I think that these are a good entry point.
W. R. Ott and J. W. Roberts. Everyday exposure to toxic pollutants.
Sci. Amer. 278 (2): 86-91 (1998).
V. G. Zartarian, W. R. Ott, and N. Duan. A quantitative definition of
exposure and related concepts. J. Exp. Anal. Environ. Epidemiol. 7(4):
411-437 (1997).
Daniel M. Byrd III, Ph.D., D.A.B.T.
8370 Greensboro Drive, Apt. 708
McLean, VA 22102
(703)848-0100
byrdd.-a-.cox.net
TO: Pharm PKBack to the Top
Several contributors asked for the citations I referenced in my
previous note (06/23/04). I think that these are a good entry point.
W. R. Ott and J. W. Roberts. Everyday exposure to toxic pollutants.
Sci. Amer. 278 (2): 86-91 (1998).
V. G. Zartarian, W. R. Ott, and N. Duan. A quantitative definition of
exposure and related concepts. J. Exp. Anal. Environ. Epidemiol. 7(4):
411-437 (1997).
Daniel M. Byrd III, Ph.D., D.A.B.T.
8370 Greensboro Drive, Apt. 708
McLean, VA 22102
(703)848-0100
byrdd.aaa.cox.net
Regards,
Daniel
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