PharmPK Discussion - Changing formulation during drug development

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On 10 Jun 2004 at 12:19:09, gregoire nicolas (icrgregoire.at.yahoo.com) sent the message

Dear all,
When changing a formulation, from capsule to tablet, during drug
development, should we assess bioequivalence or only relative
bioavailability?
Moreover, can we extrapolate DMT value obtained from the first
formulation to the DMT with the second formulation from the relative
bioavailability value?
With thanks in advance.
Nicolas Gr\0xC8goire.

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