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Does anyone know a reference that gives the human clearance values for
Chlorzoxazone and Dextromethorphan? Any help would be appreciated.
Mike
Mike,Back to the Top
Check the following references
1. Clin Pharmacol Ther. 1998 Jul;64(1):52-7. Inhibition of CYP2E1 by
chlormethiazole as measured by chlorzoxazone pharmacokinetics in
patients with alcoholism and in healthy volunteers
2. Clin Pharmacol Ther. 1996 Sep;60(3):295-307. The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans
Azher Hussain, Ph.D
Wyeth Research
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Dear Mike
Please refer to the following article for human clearance values for
dextromethorphan:
Schadel, M., D. Wu, et al. (1995). "Pharmacokinetics of
dextromethorphan and
metabolites in humans: influence of the CYP2D6 phenotype and quinidine
inhibition." Journal of Clinical Psychopharmacology 15(4): 263-9
Please be aware that dextromethorphan is metabolized to the active
metabolite dextrorphan by cytochrome P450 2D6. Due to polymorphism in
the
gene coding for CYP 2D6, clearance of dextromethorphan is highly
inter-individual. The variation in capacity to metabolize
dextromethorphan
leads to large variations in serum concentrations and AUC values for the
drug and its main metabolite, as discussed in this paper (see fig. 4 and
table 5):
Carlsson, K. C., N. O. Hoem, et al. (2004). "Analgesic effect of
dextromethorphan in neuropathic pain." Acta Anaesthesiologica
Scandinavica
48(3): 328-336.
Best regards,
Kristin
Kristin Cecilie Carlsson
School of Pharmacy
University of Oslo
Norway
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