PharmPK Discussion - Concentration Correlation Blood Hepatocytes

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On 10 May 2004 at 09:08:48, Joachim Bucher (joachim.bucher.-at-.po.uni-stuttgart.de) sent the message

Hello,
My aim of work is to simulate the drug metabolism in hepatocytes.
Therefor I need hepatic drug concentrations. Unfortunately, I've got
only blood concentrations of the drugs of my interest. So in a first
simulation I assumed concentration equality. To get nearer to the real
situation, which rough concentration factor shall i assume? (which fits
in most cases, 10, 50, 100, ...)?
Joachim Bucher
Joachim Bucher, Dipl.-Ing.
Institut fu"r Bioverfahrenstechnik
Allmandring 31
70569 Stuttgart
Germany
email: joachim.bucher.-at-.po.uni-stuttgart.de

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