PharmPK Discussion - Controlled Release-Database

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On 5 Oct 2004 at 15:55:11, "Ansgar Japes" (ansgar.japes.at.med.uni-rostock.de) sent the message


Hello,
I'm looking for all kind of information about CR-pharmaceutics,
especially  for the mathematical behavior in the intestines, the
dissolution-behavior in man.
I'm also interested in a database, where I can find out whether a drug
is a CR-drug or not.
Thank you,
Ansgar Japes

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On 5 Oct 2004 at 08:39:47, "Michael B. Bolger" (bolger.at.simulations-plus.com) sent the message


Ansgar asked:
          "I'm looking for all kind of information about
CR-pharmaceutics,
especially  for the mathematical behavior in the intestines, the
dissolution-behavior in man."
Here a few references that describe the advanced compartmental
absorption
and transit (ACAT) model that forms the basis for GastroPlus software.
Agoram B, Woltosz WS, and Bolger MB: (2001) Predicting the impact of
physiological and biochemical processes on oral drug bioavailability.
Adv.
Drug. Deliv. Rev. 50:S41-S67.
Hendriksen BA, Sanchez MF, and Bolger MB: (2003) The Composite
Solubility
Versus pH Profile and its Role in Intestinal Absorption Prediction. AAPS
Pharm. Sci. 5(1):Article 4, 2003
The following papers describe some additional theoretical approaches to
dissolution.
Dressman, J. B. and D. Fleisher (1986). "Mixing-tank model for
predicting
dissolution rate control or oral absorption." J Pharm Sci 75(2): 109-16.
Lu, A. T., M. E. Frisella and K. C. Johnson (1993). "Dissolution
modeling:
factors affecting the dissolution rates of polydisperse powders." Pharm
Res
10(9): 1308-14.
Mike
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*  Michael B. Bolger, Ph.D.
*  Director of Life Sciences and Founding Scientist
*  Phone: 707-769-1896 or (661) 723-7723 x 254
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