PharmPK Discussion - Dextromethorphan Verapamil plasma hepatic cell relationship

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On 7 Apr 2004 at 09:56:19, Joachim Bucher (joachim.bucher.at.po.uni-stuttgart.de) sent the message


Hello,
I'm interested in values for dextromethorphan and verapamil hepatic
cell concentration. Does anybody know proper references? Further, how
can I estimate hepatic cell concentration out of plasma concentration
generally, if only plasma concentration is available?
Thank you for your immediate answer
Joachim Bucher

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On 8 Apr 2004 at 09:34:59, (frederic.massiere.aaa.biopredic.com) sent the message

Dear Joachim,
You may have a look on the following article:
- Quantitative Prediction of metabolic inhibition of midazolam by
erythromycin, diltiazem and verapamil in rats: implication of
concentrative
uptake of inhibitors into liver. Yamano K et al, J Pharmacol Exp Ther
2000;
292:1118-1126.
This concerns rat species, but it is quite interesting.
Hope this helps.
Frederic
Frederic MASSIERE, PhD
Study Director
BIOPREDIC
frederic.massiere.-a-.biopredic.com

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