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I'm interested in values for dextromethorphan and verapamil hepatic
cell concentration. Does anybody know proper references? Further, how
can I estimate hepatic cell concentration out of plasma concentration
generally, if only plasma concentration is available?
Thank you for your immediate answer
Dear Joachim,Back to the Top
You may have a look on the following article:
- Quantitative Prediction of metabolic inhibition of midazolam by
erythromycin, diltiazem and verapamil in rats: implication of
uptake of inhibitors into liver. Yamano K et al, J Pharmacol Exp Ther
This concerns rat species, but it is quite interesting.
Hope this helps.
Frederic MASSIERE, PhD
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