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Hi, Does anyone have experience routinely using N,N-dimethylacetamide
(DMA)
as vehicle co-solvent for IV and PO dosing in rhesus or dog
pharmacokinetic
studies? The studies are not terminal, and the animals would be used
for
many years for additional PK studies. Therefore we would like to know if
there is data indicating DMA is safe and has no short or long term
adverse
effects that would harm the animals or compromise their use in
subsequent PK
experiments.
Thanks you for your advice,
Kathy Lyons
Sr Research Assn.
Basic Chemistry
Merck Research Labs
Rahway, NJ
732-594-7866
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