I have seen in a number of literature reports the statement to theBack to the Top
effect that oral absorption in dogs is greater than in humans." Does
anyone know of any reviews or literature that verifies this statement."
What I would like to see is a good review comparing animal models of
absorption.
Thanks in advance,
Pete bonate
Peter L. Bonate, PhD, FCP
Director, Pharmacokinetics
ILEX Oncology
4545 Horizon Hill Blvd
San Antonio, TX" 78229
phone: 210-949-8662
fax: 210-949-8219
email: pbonate.aaa.ilexonc.com
[Dressman and Yamada have a chapter in Pharmaceutical Bioquivalence, ed
Welling et al. and Models for assessing drug absorption and metabolism,
ed, Borchardt et al. maybe a start (details
http://www.boomer.org/pkin/book.html) - db]
PharmPK - Discussions about PharmacokineticsBack to the Top
Pharmacodynamics and related topics
Dear Peter Bonate,
find a helpfull article below.
[Chiou, W.L. and Barve, A. 1998 Linear correlation of the fraction of
oral dose absorbed of 64 drugs between humans and rats, Pharm. Res.,
15(11) pp?? - db]
Best regards
Hans Markus
Dr. Hans Markus Bender
Merck KGaA
Institute of Drug Metabolism and Pharmacokinetics
Am Feld 32
D-85567 Grafing
[Germany]
Tel: 08092 / 7008-14
Fax: 08092 / 7008-99
e-mail: hansmarkus.bender.at.merck.de
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