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I am having difficulty doing BE comparison using Winonlin. Can some one
out
there help?
1. Where do you specify whether you want to compare AUC or Cmax.
2. Do I have to have AUC calculated prior to comparing doing BE
comparison?
Please let me know
Thanks
Argaw Kidane
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Hi Argaw,
Please see below your questions and my answers.
Q1. Where do you specify whether you want to compare AUC or Cmax.
Joseph: In WinNonlin BE Wizard, see BE Fixed Effect screen and specify
your parameter (AUC or Cmax) in the Dependent Variables.
Q2. Do I have to have AUC calculated prior to comparing doing BE
comparison?
Joseph: Yes you need to calculate the parameters before using BE Wizard
but you don't have to transform the parameters as WinNolin will give you
an option to transform in the Wizard.
For more detail, I would recommend you to read WinNonlin Examples Guide.
Thanks,
Joseph Kim, Ph.D., RPh.
Clinical Pharmacokineticist
Antiviral CPK/Modelling & Simulation
GlaxoSmithKline
joseph.y.kim.at.gsk.com
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)