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In toxicological studies, lipophilic chemicals,e.g.,hexachlorobenzene,PCBs, are often orally administered with an oily vehicle (e.g.,corn oil). Due to the introduction of oil to the GI lumen, could single oral dosing, intermittent dosing (every other day),and daily dosing regimens result in different absorption and fecal excretion behaviors of a same chemical? My instinctive guess is that,since the oil is introduced in different frequencies and exists in the GI lumen in different amounts/concentrations,the absorption and fecal excretion behavior shoud be affected.Is this correct? The literature
search did not give me related information.
The background of this question is when the PK data of
hexachlorobenzene from the above three regimens are modeled,each data set must have a particular set of absorption and exsorption rate constants,i.e.,a set of the rate constants cannot fit the three data sets.
Could someone give advices or recommend related references? Thanks a lot.
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