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I want to know or more about the enterohepatic circle and all factors
could influence in the intensify, time, and appearance the double peak.
I have data in dogs after oral administration, where in same time could
appear the double peak more clear, and in other cases ( after single or
repeated dose) in the same animal, not is possible to observe any peak.
And in same animal yes and in other not.
The questions is:, are there very important biopharmaceutical factors
(intraday) that can explain a very great variability in a enterohepatic
circle, not related with interindividual variability, dose or
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